More About BIAPSS

Liquid-liquid phase separation of partially or fully disordered proteins has recently emerged as the critical mechanism underlying cellular order and regulation in biology. A significant knowledge gap, however, remains before we can unlock the sequence "codes" of phase-separation, thereby paving the way for the design of new medically and synthetically relevant phase separating sequences. To address this concern, we are compiling a centralized repository of sequence-based analysis for LLPS proteins to learn about the biophysics of protein phase-separation in a data-driven way.

BIAPSS is a comprehensive web platform for interactive statistical analysis of liquid-liquid phase-separated biological systems deposited in PhaSePro and LLPSDB databases. The comparison and consensus of a plethora of proven bioinformatic tools provides a thorough and up to date description of various properties of proteins based on their amino acid sequence.
The results of the analysis can be visualized and downloaded both as publication-quality images as well as raw data for further analysis. We believe that the open access and open-source nature of our database will facilitate the work of other researchers and accelerate further progress towards uncovering the molecular basis of LLPS phenomena.